Activation of FGF-23 Mediated Vitamin D Degradative Pathways by Cholecalciferol
نویسندگان
چکیده
منابع مشابه
FGF-23, vitamin D and calcification: the unholy triad.
Recent studies have changed the commonly held view that phosphate is mostly needed for normal skeletal growth and development. Extensive research in the last decade has identified numerous other essential dynamic functions for phosphate, ranging from signalling to energy metabolism. Abnormal phosphate homeostasis potentially affects functional activities of almost any organ system. Despite its ...
متن کاملFGF-23, Klotho and Vitamin D Levels in Scleroderma
BACKGROUND Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interfere with calcium and phosphate metabolism. The purpose of this study was to e...
متن کاملfgf-23, klotho and vitamin d levels in scleroderma
background: scleroderma is a chronic connective tissue disease of unknown etiology. vitamin d and parathyroid hormone (pth) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. klotho, the co-receptor of the fibroblast growth factor 23 (fgf-23), can interfere with calcium and phosphate metabolism. the purpose of this study was to ...
متن کاملFGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone.
The functional interaction between fibroblast growth factor 23 (FGF-23) and Klotho in the control of vitamin D and phosphate homeostasis is manifested by the largely overlapping phenotypes of Fgf23- and Klotho-deficient mouse models. However, to date, targeted inactivation of FGF receptors (FGFRs) has not provided clear evidence for an analogous function of FGFRs in this process. Here, by means...
متن کاملVitamin D suppresses cellular pathways of diabetes complication in liver
Objective(s): The aim of this study was to investigate the effect of vitamin D on glucose metabolism, as well as the expression of five key genes involved in the development of diabetes complications in liver tissue of diabetic rats. Materials and Methods: Twenty-four male Sprague–Dawley rats were randomly divided into three groups (8 ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2014
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2014-1308